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Oryx feature comparison chart





Sitting Drop

Vapor diffusion multiple drops per reservoir, single protein

Vapor diffusion multiple drops per reservoir, 2 proteins

Vapor diffusion multiple drops per reservoir, 3 proteins


Vapor diffusion, Microseed Matrix Screening

Vapor Diffusion, additive experiments


Hanging Drop


Vapor Diffusion with up to 5 drops per cover slide


with automatic oiling


Additive experiments    


Microseed Matrix Screening





Quick-and-easy 2-D grid, 3 ingredients



Quick-and-easy 2-D grid, 4 ingredients



7-D optimization grids



Central Composite, multi-variate experimental designs (7-channel)



Rapid Reservoir filling for Stock Plates, Sitting Drop and Hanging Drop Optimization




Microlytic Crystal Former filling


Fluidigm filling


LCP Upgrade

Compatible with LCP dispensing arm add-on



The Major Differences between Oryx8, Oryx4 and OryxNano

Oryx8 is the flagship Douglas Instruments protein crystallization robot. It can set up sitting drops down to 100 + 100 nl and up to 2 + 2 µl for 96 wells. For hanging drop experiments up to five drops can be set up per cover slide, with volumes up to 8 + 8 µl.  (For screening experiments the reservoirs must be predispensed by some other method such as a 12-channel pipette. For optimization experiments the reservoirs are filled automatically.)  Standard screening, additive and microseeding experiments are included as well as microbatch-under-oil screens (also down to 100 + 100 nl).  Optimization experiments can be carried out  using up to 7 ingredients with full pH control, including multi-variate designs such as the Central Composite. In addition, quick-and-easy 2-D grid optimizations with up to 4 ingredients can be carried out in a few minutes. 

Oryx4 is the product for those users who do not want to do multi-variate optimization. As with the Oryx8, it performs standard screening, additive, microseeding, sitting drop and hanging drop experiments and microbatch-under-oil screens (also down to 100+100 nl). Oryx4 can be upgraded to Oryx8 if multi-variate optimization becomes a requirement.

OryxNano is a compact option which has the capability of the Oryx4, except for hanging drop, microbatch and additive experiments. OryxNano can do quick-and-easy 2-D grid optimizations with up to 4 ingredients.



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