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Set up Sitting Drop and Microbatch-Under-Oil experiments at the same time

Available at the press of one button!

        -  Two screening methods
        -  Up to 4 drop ratios
        -  Additives (e.g. seed stock)
Video of Combined Microbatch and Vapor Diffusion experiment
Video of Microbatch-Under-Oil Optimization Gradient experiment

Visit our booth at ACA, Denver for more information.

        -  20 µL of protein is enough for both methods (2x 96x 100+100 nL drops)
        -  Automatic oil dispensing onto aqueous drop. This give much more consistent drop size, shape and mixing

Advantages of the microbatch under oil technique include:

        -  Microbatch reduces skins on the drop surface.
        -  Microbatch conditions are easier to scale up.
        -  The rate of evaporation can be controlled by oil. (Paraffin gives slow evaporation, silicone gives rapid evaporation.) For optimization under oil pure paraffin oil can be used, which reduces evaporation to a minimum

Douglas Instruments Vapour Batch plates are available in Hydrophillic or Hydrophobic material. Hydrophillic are often the best option for screening. Hydrophobic are useful for some optimization experiments and low surface tension solutions.


To request a quote or demonstration please contact

For any technical or product support questions please contact

For anything else please contact

Douglas Instruments will be at the following meetings:

Visit our booth and pick up a Microseeding Tool Kit containing everything you need to do a MMS microseeding experiment. The kit includes:
     -  Hampton Research Seed Bead
     -  Hampton Research Crystal Crusher
     -  Instructions and advice for making a seed stock, and setting up an MMS experiment.
     -  References to papers about MMS microseeding and 'cross-seeding'.

ACA 2016 Denver

July 22nd - 26th.

ECM 2016 Basel

August 28th - 1st September.

CSCM 24, Croatia

September 21st - 25th.

HEC 19, Warberg

September 29th - October 1st.

Recent mentions of Douglas Instruments products

Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression

Oda, Shun-ichiro, Takeshi Noda, Kaveesha J. Wijesinghe, Peter Halfmann, Zachary A. Bornholdt, Dafna M. Abelson, Tammy Armbrust, Robert V. Stahelin, Yoshihiro Kawaoka, and Erica Ollmann Saphire

Journal of virology 90.4 1839-1848 (2016)

Structural determinants of reductive terpene cyclization in iridoid biosynthesis

Hajo Kries, Lorenzo Caputi, Clare E M Stevenson, Mohammed O Kamileen, Nathaniel H Sherden, Fernando Geu-Flores, David M Lawson & Sarah E O'Connor

Nature chemical biology, 12(1), pp.6-8. (2016)

Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae

Anton Brausemann, Stefan Gerhardt, Anne-Kathrin Schott, Oliver Einsle, Andreas Große-Berkenbusch, Nils Johnsson, Thomas Gronemeyer

Journal of structural biology (2016)

The molecular characterizations of surface proteins hemagglutinin and neuraminidase from recent H5Nx avian influenza viruses

Hua Yang, Paul J. Carney, Vasiliy P. Mishin, Zhu Guo, Jessie C. Chang, David E. Wentworth, Larisa V. Gubareva and James Stevens

Journal of Virology. JVI-00180 (2016)

Structure-Function Relationships in L-Amino Acid Deaminase, a Flavoprotein Belonging to a Novel Class of Biotechnologically Relevant Enzymes

Paolo Motta, Gianluca Molla, Loredano Pollegioni and Marco Nardini

Journal of Biological Chemistry, pp.jbc-M115. 2016



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Douglas Instruments Ltd
East Garston
Berkshire RG17 7HD
United Kingdom

Tel: + (44) 1488 649090
US toll free: 1-877-225-2034

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