Douglas Vapor Batch Plate

The Douglas Vapor Batch Plate is designed for both microbatch and vapor diffusion (sitting drop) crystallization.  It has 96 wells in the center and several reservoirs around the outside.  The reservoirs can be used to preserve microbatch crystals by preventing drying out of the wells, or they can be used for simple vapor diffusion experiments where up to 96 wells are equilibrated against a single precipitant (preliminary experiments suggest that this method finds more hits in screening experiments than the conventional method of using the same solution in the reservoir and the drop).

Two versions of the Vapor Batch plate are available: treated (hydrophilic) and untreated (hydrophobic). We recommend the treated hydrophilic version for most applications including screening. The untreated hydrophobic plates are useful for some optimization experiments and for some detergents and proteins. Experiments dispensed to the treated hydrophilic plates tend form disc shaped drops whilst experiments dispensed to the untreated hydrophobic plate tend to form rounder taller drops - Please see example drops in image below

Advantages:

Please click here for detailed instructions for using the Douglas Vapor Batch Plate.

Holders are available from Douglas Instruments to provide a regular Linbro or  SBS ( i.e. regular 96-well) footprint. 

The Douglas Vapor Batch Plate was designed and is manufactured by Douglas Instruments.   It can be obtained from Douglas Instruments and from Hampton Research.

Douglas Instruments is running a competition for the best use of the Douglas Vapor Batch Plate.

Specification

Ordering information:

For prices see the Products page.