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Douglas Instruments News

March 2019

Douglas Instruments has released an updated additive screening experiment script. New features include:

  • rMMS with additive screening
  • Faster experiment time. 18 mins* for a typical screen

    *(Dependent on drop size and viscosity - 18 minutes for 96 x 1 drops: 200 nl protein, 100 nl precipitant, 50 nl additive screen, 50 nl seed stock).


    May 2018

    Douglas Instruments is collaborating with Xtal Concepts GmbH to develop methods for improving productivity in cryoEM via the use of multi-well in situ DLS for pre-characterizing samples prior to cryo analysis.

    Multi-well in situ dynamic light scattering (mi-DLS) can be performed by the SpectroLight 610 from XtalConcepts. Oryx robots can deliver appropriately small samples under oil. Suitable experiments include additive screens (such as the DIXC screen) that includes chaotropes, kosmotropes, detergents, buffers, substrates etc. These can be followed up with multivariate optimization experiments.



    Nov 2017

    Douglas Instruments has introduced new 2D grid optimization experiments with large volume reservoir filling capability. Please click here to see a youtube video of a 24 Well Hanging Drop - Simple pH vs [precipitant] Gradient Optimization experiment.



    May 2016

    Douglas Instruments has developed a method of further scaling up Lipidic Cubic Phase (LCP) experiments. The method can be used to prepare larger volumes of micro crystals for use as an LCP seed stock or for serial data collection



    March 2016

    Douglas Instruments has published a study adapting the rMMS Microseeding method for use with Lipidic Cubic Phase (LCP): A novel microseeding method for the crystallization of membrane proteins in lipidic cubic phase. The method involves scaling up crystallization conditions and dispensing LCP containing micro crystals to a fresh screen. Our trials showed an increase in crystallization hits of almost an order of magnitude.



    May 2014

    Douglas Instruments has released the Lipidic Cubic Phase (LCP) dispensing option for Oryx8 and Oryx4.  The arm mounted positive displacement syringe drive can dispense LCP volumes as small as 10 nl and up to 1 Ál or larger. The LCP dispensing arm is designed to be simple to use - yet make use of the powerful range of experiment scripts available on Oryx systems.



    October 2013

    Vapor diffusion optimization is now available with Oryx8. The robot can quickly fill the reservoirs of sitting drop or source plates with essentially unlimited volumes using the air-driven 1 ml tip in combination with the 7-bore microtip. The reservoirs are filled first, and then the drops can be dispensed independently.



    April 2013

    Douglas Instruments has released a new experiment script for 24 well cover slide dispensing. It is now possible to dispense screening, optimization or seeding experiments to 22mm or 18mm cover slides.




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    Douglas Instruments are attending the following meetings:

    3 November - 5 November 2019:
    PSDI 2019, Hinxton, UK

    17 December - 20 December 2019:
    AsCA 2019, National University of Singapore


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