Measuring Protein Aggregation and Stability Using High-Throughput Biophysical Approaches
Kwan, T.O., Kolek, S.A., Danson, A.E., Reis, R.I., Camacho, I.S., Stewart, P.D.S. and Moraes, I.
Frontiers in Molecular Biosciences, p.481 (2022)

A novel microseeding method for the crystallization of membrane proteins in lipidic cubic phase
Kolek, S. A., Braeuning, B., & Shaw Stewart, P. D
Acta Crystallographica Section F: Structural Biology Communications 72.4 (2016): 307-312

Automation in biological crystallization
Shaw Stewart, P.D, & Mueller-Dieckmann, J.
Acta Crystallographica Section F: Structural Biology Communications 70.6 (2014): 686-696

Membrane protein structure determination the next generation
Moraes, I., Evans, G., Sanchez-Weatherby, J., Newstead, S., & Shaw Stewart, P. D.
Biochimica et Biophysica Acta (BBA)-Biomembranes 1838.1 (2014): 78-87

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity
Abuhammad, A., Lowe, E. D., McDonough, M. A., Shaw Stewart, P. D., Kolek, S. A. , Sim, E., & Garman, E. F.
Acta Crystallographica Section D: Biological Crystallography 69.8 (2013): 1433-1446

Random microseeding: a theoretical and practical exploration of seed stability and seeding techniques for successful protein crystallization
Shaw Stewart, P. D., Kolek, S. A., Briggs, R. A., Chayen, N. E., & Baldock, P. F.
Crystal Growth & Design 11.8 (2011): 3432-3441

Full list of references
A list of publications describing Oryx, theoretical studies using Oryx and New methods. This list includes publications by Douglas Instruments


Sample preparation for frontier structural biology
May 2023

Microseed Matrix Screening with Lipidic Cubic Phase
June 2016

Microbatch-under-oil for XFEL
January 2016

Advanced Microseeding including LCP
December 2015

Robotic LCP dispensing
July 2015

Microseed it!
October 2014

Coupling counterdiffusion and micro-seeding techniques to increase protein crystallization succeed

Articles and Research Reports

Further data mining of the PDB includes the concentration of protein, the temperature, and the pH used in crystallization experiments.
Research report 10, September 2011

Microseed Matrix Screening (MMS).
Research report 9, August 2007

Data mining of the PDB reveals the most successful organic and salt precipitants
Research report 8, August 2006

Screening: a summary of studies comparing microbatch with vapor diffusion.
Research report 7, June 2003

Membrane proteins crystallized using microbatch. We know of four so far.
Research report 6, March 2001

Analysis of open reading frames from Pyrococcus furiosus
Research report 5, June 1999

Practical Experimental Design Techniques for Automatic and Manual Protein Crystallization
(published in the Journal of Crystal Growth 196 (1999) 665 - 673)

Research report 4, August 1998

A Comparison of Microbatch and Vapor Diffusion for Initial Screening of Crystallization Conditions (published in the Journal of Crystal Growth 168 (1996) 170-174)
Research report 3, November 1995

Harvesting Crystals from Microbatch for Cryocrystallography
Research report 2, October 1995

Crystallization of a protein by microseeding after establishing its phase diagram
Research report 1, August 1995



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