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Douglas Instruments News

January 2020

The South Coast Biosciences (SoCoBio) Doctoral Training Partnership is offering a PhD student a unique opportunity to undertake research and training in structural biology and microfluidics.

The PhD will optimise nano-crystallisation to study two high value targets. Micro-seeding approaches are developed in collaboration with the highly innovative CASE partner Douglas Instruments [2]. Novel high-throughput approaches in nano-crystallisation using microfluidic platforms are developed at Southampton [3].

Primary supervisor:
Dr Ivo Tews, Biological Sciences, University of Southampton
Dr S. Mark Roe, School of Life Sciences, University of Sussex
Dr Jonathan West, Medicine, University of Southampton




December 2019

Douglas Instruments in collaboration with the National Physical Laboratory (NPL, Teddington, UK) have been awarded a grant by Innovate UK. The project will aim to develop methods to improve the efficiency and throughput of structure determination especially by cryoEM.



March 2019

Douglas Instruments has released an updated additive screening experiment script. New features include:

  • Additive screening with microseeding can now be performed
  • Reduced total dispensing time



    May 2018

    Douglas Instruments is collaborating with Xtal Concepts GmbH to develop methods for improving productivity in cryoEM via the use of multi-well in situ DLS for pre-characterizing samples prior to cryo analysis.

    Multi-well in situ dynamic light scattering (mi-DLS) can be performed by the SpectroLight 610 from XtalConcepts. Oryx robots can deliver appropriately small samples under oil. Suitable experiments include additive screens (such as the DIXC screen) that includes chaotropes, kosmotropes, detergents, buffers, substrates etc. These can be followed up with multivariate optimization experiments.



    Nov 2017

    Douglas Instruments has introduced new 2D grid optimization experiments with large volume reservoir filling capability. Please click here to see a youtube video of a 24 Well Hanging Drop - Simple pH vs [precipitant] Gradient Optimization experiment.



    May 2016

    Douglas Instruments has developed a method of further scaling up Lipidic Cubic Phase (LCP) experiments. The method can be used to prepare larger volumes of micro crystals for use as an LCP seed stock or for serial data collection



    March 2016

    Douglas Instruments has published a study adapting the rMMS Microseeding method for use with Lipidic Cubic Phase (LCP): A novel microseeding method for the crystallization of membrane proteins in lipidic cubic phase. The method involves scaling up crystallization conditions and dispensing LCP containing micro crystals to a fresh screen. Our trials showed an increase in crystallization hits of almost an order of magnitude.




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    Douglas Instruments are attending the following meetings:

    ACA 2020, San Diego, USA
    ACA Virtual Meeting
    2 August - 7 August 2020

    BCA and BACG Joint Online Meeting 2021
    29 March - 1 April 2021

    IUCr 2021, Prague, Czech Republic
    14 August - 22 August 2021


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